| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | SHG | S | S% | Hits | P/GP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Daniel Briere | C | BUF | 80 | 34 | 62 | 96 | +38 | 86 | 5 | 0 | 20:26 | 9 | 1 | 201 | 16.9 | 102 | 1.20 |
| Sidney Crosby | C | BUF | 79 | 24 | 59 | 83 | +21 | 39 | 2 | 2 | 21:21 | 10 | 0 | 240 | 10.0 | 99 | 1.05 |
| Derek Roy | LW | BUF | 79 | 31 | 43 | 74 | +35 | 108 | 6 | 0 | 19:25 | 6 | 2 | 200 | 15.5 | 105 | 0.94 |
| Marian Gaborik | RW | BUF | 76 | 36 | 35 | 71 | +21 | 36 | 9 | 1 | 19:17 | 3 | 4 | 194 | 18.6 | 96 | 0.93 |
| Marc-Andre Bergeron | D | BUF | 81 | 16 | 43 | 59 | -6 | 78 | 1 | 0 | 22:48 | 5 | 0 | 187 | 8.6 | 117 | 0.73 |
| Jason Pominville | RW | BUF | 73 | 19 | 36 | 55 | +23 | 24 | 4 | 1 | 18:11 | 6 | 0 | 158 | 12.0 | 74 | 0.75 |
| Thomas Vanek | LW | BUF | 78 | 18 | 36 | 54 | +13 | 55 | 1 | 2 | 15:36 | 5 | 0 | 150 | 12.0 | 46 | 0.69 |
| Dainius Zubrus | LW | BUF | 79 | 26 | 25 | 51 | +37 | 71 | 2 | 0 | 14:50 | 4 | 0 | 151 | 17.2 | 119 | 0.65 |
| Chris Drury | C | BUF | 82 | 18 | 28 | 46 | +10 | 54 | 3 | 0 | 15:53 | 0 | 4 | 158 | 11.4 | 55 | 0.56 |
| Chris Pronger | D | BUF | 76 | 11 | 35 | 46 | +26 | 120 | 3 | 0 | 24:24 | 0 | 0 | 155 | 7.1 | 188 | 0.61 |
| Jan Bulis | LW | BUF | 83 | 26 | 19 | 45 | -40 | 78 | 3 | 1 | 20:23 | 7 | 0 | 187 | 13.9 | 103 | 0.54 |
| Henrik Tallinder | D | BUF | 78 | 11 | 31 | 42 | +14 | 36 | 0 | 0 | 22:58 | 3 | 0 | 137 | 8.0 | 131 | 0.54 |
| Chris Simon | LW | BUF / CHI | 80 | 12 | 20 | 32 | -5 | 253 | 1 | 0 | 12:30 | 2 | 0 | 92 | 13.0 | 92 | 0.40 |
| Jochen Hecht | RW | BUF | 82 | 13 | 18 | 31 | +5 | 52 | 1 | 0 | 11:00 | 0 | 0 | 99 | 13.1 | 62 | 0.38 |
| Jim Vandermeer | D | BUF / LAK / WSH / VAN / NJD | 74 | 7 | 23 | 30 | -4 | 158 | 1 | 0 | 18:55 | 0 | 1 | 106 | 6.6 | 124 | 0.41 |
| Anton Volchenkov | D | BUF | 79 | 3 | 26 | 29 | +5 | 76 | 1 | 0 | 22:44 | 0 | 0 | 111 | 2.7 | 237 | 0.37 |
| Sean Hill | D | BUF | 77 | 6 | 22 | 28 | +34 | 84 | 0 | 0 | 23:13 | 2 | 0 | 125 | 4.8 | 242 | 0.36 |
| Adam Mair | RW | BUF | 82 | 11 | 7 | 18 | +12 | 61 | 2 | 0 | 6:59 | 0 | 1 | 46 | 23.9 | 63 | 0.22 |
| Paul Gaustad | C | BUF | 70 | 5 | 13 | 18 | -7 | 69 | 1 | 0 | 8:51 | 1 | 1 | 55 | 9.1 | 75 | 0.26 |
| Jay McKee | D | BUF | 69 | 7 | 9 | 16 | +25 | 80 | 1 | 0 | 18:21 | 0 | 1 | 87 | 8.0 | 151 | 0.23 |
| Daniel Paille (R) | LW | BUF | 13 | 1 | 4 | 5 | +1 | 14 | 0 | 0 | 12:37 | 0 | 0 | 20 | 5.0 | 10 | 0.38 |
| Andrew Peters | LW | BUF | 44 | 1 | 1 | 2 | -5 | 78 | 0 | 0 | 4:35 | 0 | 0 | 20 | 5.0 | 27 | 0.05 |
| Mike Weber (R) | D | BUF | 4 | 0 | 1 | 1 | -2 | 6 | 0 | 0 | 13:15 | 0 | 0 | 2 | 0.0 | 1 | 0.25 |
| Drew Stafford (R) | RW | BUF | 12 | 0 | 1 | 1 | +2 | 6 | 0 | 0 | 4:35 | 0 | 0 | 4 | 0.0 | 4 | 0.08 |
| Cody McLeod (R) | LW | BUF | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0:40 | 0 | 0 | 0 | - | 0 | 0.00 |
| Derek Meech (R) | D | BUF | 3 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 19:40 | 0 | 0 | 2 | 0.0 | 2 | 0.00 |
| Chris Thorburn (R) | C | BUF | 4 | 0 | 0 | 0 | -1 | 12 | 0 | 0 | 3:45 | 0 | 0 | 0 | - | 1 | 0.00 |
| Clarke MacArthur (R) | C | BUF | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1:33 | 0 | 0 | 4 | 0.0 | 1 | 0.00 |
| 28 Skaters | 1649 | 336 | 597 | 933 | - | 1736 | 47 | 7 | - | 63 | 15 | 2891 | - | 2327 | 12.58 |