| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | SHG | S | S% | Hits | P/GP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sidney Crosby | C | BUF | 81 | 24 | 56 | 80 | +12 | 76 | 3 | 0 | 22:41 | 3 | 1 | 220 | 10.9 | 149 | 0.99 |
| Daniel Briere | C | BUF | 78 | 20 | 41 | 61 | -6 | 69 | 2 | 1 | 19:38 | 6 | 0 | 207 | 9.7 | 91 | 0.78 |
| Chris Pronger | D | BUF | 78 | 10 | 41 | 51 | +5 | 68 | 2 | 0 | 25:31 | 2 | 0 | 155 | 6.5 | 195 | 0.65 |
| Marian Gaborik | RW | BUF | 68 | 26 | 22 | 48 | +8 | 10 | 1 | 0 | 17:08 | 5 | 0 | 150 | 17.3 | 66 | 0.71 |
| Chris Drury | C | BUF | 79 | 22 | 26 | 48 | -19 | 47 | 4 | 0 | 20:42 | 9 | 1 | 174 | 12.6 | 139 | 0.61 |
| Jochen Hecht | LW | BUF | 77 | 19 | 28 | 47 | -11 | 30 | 1 | 0 | 19:36 | 4 | 2 | 164 | 11.6 | 114 | 0.61 |
| Thomas Vanek (R) | LW | BUF | 82 | 12 | 34 | 46 | -23 | 66 | 4 | 0 | 18:46 | 5 | 0 | 176 | 6.8 | 90 | 0.56 |
| Henrik Tallinder | D | BUF | 77 | 8 | 27 | 35 | -22 | 56 | 1 | 0 | 22:46 | 4 | 1 | 127 | 6.3 | 119 | 0.45 |
| Dmitri Kalinin | D | BUF | 79 | 7 | 24 | 31 | +8 | 78 | 1 | 0 | 20:24 | 3 | 0 | 144 | 4.9 | 114 | 0.39 |
| Andrew Cassels | C | BUF | 53 | 11 | 18 | 29 | +1 | 18 | 3 | 0 | 20:58 | 2 | 0 | 114 | 9.6 | 58 | 0.55 |
| Jim Vandermeer | D | BUF | 77 | 6 | 17 | 23 | +22 | 91 | 1 | 0 | 19:55 | 1 | 0 | 88 | 6.8 | 163 | 0.30 |
| Grant Marshall | RW | BUF | 81 | 11 | 10 | 21 | -6 | 79 | 1 | 0 | 10:15 | 0 | 0 | 75 | 14.7 | 107 | 0.26 |
| Sean Hill | D | BUF | 74 | 6 | 15 | 21 | -14 | 53 | 1 | 0 | 13:16 | 1 | 0 | 93 | 6.5 | 117 | 0.28 |
| Chris Simon | LW | BUF | 72 | 8 | 8 | 16 | -6 | 273 | 1 | 0 | 12:35 | 1 | 0 | 88 | 9.1 | 135 | 0.22 |
| Jason Pominville (R) | RW | BUF | 74 | 7 | 9 | 16 | -4 | 17 | 3 | 0 | 9:58 | 2 | 0 | 74 | 9.5 | 39 | 0.22 |
| Andrew Peters | LW | BUF | 71 | 3 | 11 | 14 | -14 | 272 | 0 | 0 | 11:52 | 1 | 0 | 60 | 5.0 | 159 | 0.20 |
| Derek Roy | LW | BUF | 60 | 7 | 6 | 13 | -5 | 50 | 1 | 0 | 7:57 | 1 | 0 | 50 | 14.0 | 37 | 0.22 |
| Paul Gaustad (R) | C | BUF | 47 | 3 | 6 | 9 | -3 | 10 | 3 | 0 | 7:59 | 1 | 0 | 41 | 7.3 | 43 | 0.19 |
| Adam Mair | RW | BUF | 31 | 3 | 2 | 5 | +1 | 27 | 0 | 0 | 6:58 | 0 | 0 | 26 | 11.5 | 26 | 0.16 |
| Jan Hejda | D | BUF | 6 | 0 | 1 | 1 | +2 | 2 | 0 | 0 | 10:00 | 0 | 0 | 4 | 0.0 | 1 | 0.17 |
| Mark Popovic (R) | D | BUF | 7 | 0 | 1 | 1 | +1 | 11 | 0 | 0 | 10:51 | 0 | 0 | 1 | 0.0 | 2 | 0.14 |
| Doug Janik | D | BUF | 8 | 0 | 1 | 1 | -3 | 30 | 0 | 0 | 14:53 | 0 | 0 | 7 | 0.0 | 16 | 0.13 |
| Trevor Gillies | LW | BUF | 8 | 0 | 1 | 1 | -1 | 16 | 0 | 0 | 7:08 | 0 | 0 | 5 | 0.0 | 9 | 0.13 |
| Chris Thorburn (R) | C | BUF | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4:00 | 0 | 0 | 3 | 0.0 | 0 | 0.00 |
| Drew Stafford (R) | RW | BUF | 6 | 0 | 0 | 0 | +1 | 0 | 0 | 0 | 6:50 | 0 | 0 | 4 | 0.0 | 1 | 0.00 |
| 25 Skaters | 1376 | 213 | 405 | 618 | - | 1449 | 33 | 1 | - | 51 | 5 | 2250 | - | 1990 | 8.92 |