| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | SHG | S | S% | Hits | P/GP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ilya Kovalchuk | LW | BUF | 83 | 25 | 35 | 60 | -6 | 117 | 3 | 3 | 22:57 | 9 | 1 | 214 | 11.7 | 195 | 0.72 |
| Martin Havlat | LW | OTT / BUF / ATL | 77 | 24 | 36 | 60 | +11 | 44 | 3 | 1 | 20:55 | 7 | 0 | 205 | 11.7 | 104 | 0.78 |
| Chris Drury | C | BUF | 79 | 25 | 31 | 56 | +1 | 148 | 8 | 0 | 18:44 | 11 | 0 | 201 | 12.4 | 172 | 0.71 |
| Marian Gaborik | RW | BUF | 79 | 25 | 29 | 54 | +12 | 64 | 3 | 2 | 16:25 | 3 | 2 | 181 | 13.8 | 84 | 0.68 |
| J-P Dumont | LW | BUF / OTT | 81 | 22 | 32 | 54 | +1 | 63 | 4 | 0 | 18:50 | 4 | 1 | 172 | 12.8 | 104 | 0.67 |
| Jochen Hecht | LW | BUF | 77 | 20 | 34 | 54 | -16 | 83 | 1 | 0 | 20:16 | 8 | 1 | 171 | 11.7 | 97 | 0.70 |
| Daniel Briere | C | BUF | 82 | 22 | 29 | 51 | -3 | 138 | 2 | 0 | 19:37 | 5 | 0 | 195 | 11.3 | 101 | 0.62 |
| Sean Hill | D | BUF | 81 | 8 | 32 | 40 | -10 | 112 | 1 | 1 | 22:56 | 4 | 0 | 146 | 5.5 | 196 | 0.49 |
| Dmitri Kalinin | D | BUF | 72 | 9 | 24 | 33 | +5 | 110 | 2 | 0 | 21:45 | 2 | 0 | 92 | 9.8 | 88 | 0.46 |
| Sandis Ozolinsh | D | BUF / OTT / LAK | 80 | 7 | 21 | 28 | -8 | 65 | 0 | 0 | 20:00 | 0 | 0 | 144 | 4.9 | 104 | 0.35 |
| Joni Pitkanen | D | BUF | 82 | 4 | 24 | 28 | -19 | 92 | 1 | 0 | 21:03 | 2 | 0 | 108 | 3.7 | 147 | 0.34 |
| Matthew Barnaby | RW | BUF | 82 | 11 | 12 | 23 | +6 | 149 | 4 | 0 | 11:29 | 0 | 0 | 94 | 11.7 | 108 | 0.28 |
| Barret Jackman | D | BUF | 68 | 4 | 15 | 19 | 0 | 116 | 1 | 0 | 19:50 | 1 | 0 | 94 | 4.3 | 146 | 0.28 |
| Mike Grier | RW | BUF | 79 | 6 | 11 | 17 | -17 | 40 | 1 | 0 | 10:55 | 3 | 0 | 80 | 7.5 | 54 | 0.22 |
| Henrik Tallinder | D | BUF | 73 | 2 | 12 | 14 | -4 | 71 | 0 | 0 | 17:28 | 0 | 0 | 77 | 2.6 | 84 | 0.19 |
| Sean Avery | LW | BUF | 80 | 1 | 6 | 7 | -9 | 195 | 0 | 0 | 5:45 | 0 | 0 | 38 | 2.6 | 52 | 0.09 |
| Jay McKee | D | BUF | 81 | 2 | 4 | 6 | -14 | 77 | 1 | 0 | 16:15 | 2 | 0 | 73 | 2.7 | 142 | 0.07 |
| Steve McCarthy | D | BUF | 27 | 1 | 3 | 4 | +1 | 32 | 0 | 0 | 15:51 | 0 | 0 | 25 | 4.0 | 27 | 0.15 |
| Thomas Vanek (R) | RW | BUF | 16 | 1 | 1 | 2 | -8 | 36 | 0 | 0 | 11:00 | 1 | 0 | 27 | 3.7 | 15 | 0.13 |
| Marc Bergevin | D | BUF | 6 | 0 | 2 | 2 | +1 | 2 | 0 | 0 | 16:10 | 0 | 0 | 0 | - | 4 | 0.33 |
| Andrew Alberts | D | BUF | 11 | 1 | 0 | 1 | +1 | 49 | 0 | 0 | 17:16 | 1 | 0 | 11 | 9.1 | 15 | 0.09 |
| Derek Roy | C | BUF | 8 | 0 | 1 | 1 | +2 | 2 | 0 | 0 | 10:08 | 0 | 0 | 5 | 0.0 | 8 | 0.13 |
| Jason Pominville (R) | RW | BUF | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0.00 |
| Paul Gaustad (R) | C | BUF | 10 | 0 | 0 | 0 | -2 | 20 | 0 | 0 | 7:18 | 0 | 0 | 8 | 0.0 | 7 | 0.00 |
| Adam Mair | LW | BUF | 15 | 0 | 0 | 0 | -3 | 22 | 0 | 0 | 7:00 | 0 | 0 | 8 | 0.0 | 9 | 0.00 |
| 25 Skaters | 1430 | 220 | 394 | 614 | - | 1847 | 35 | 7 | - | 63 | 5 | 2369 | - | 2063 | 8.48 |