| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | PPP | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sidney Crosby | C | BUF | 79 | 31 | 49 | 80 | +6 | 16 | 9 | 3 | 22:09 | 5 | 16 | 0 | 264 | 11.7 | 8 | 63 | 1.01 | 53 | 0 |
| Jason Pominville | RW | BUF | 82 | 27 | 42 | 69 | +14 | 8 | 3 | 1 | 19:25 | 5 | 15 | 0 | 275 | 9.8 | 11 | 25 | 0.84 | 46 | 0 |
| Thomas Vanek | LW | BUF | 82 | 22 | 43 | 65 | +12 | 30 | 3 | 3 | 20:12 | 4 | 14 | 0 | 226 | 9.7 | 4 | 82 | 0.79 | 33 | 0 |
| Mike Ribeiro | C | SJS / BUF | 80 | 21 | 38 | 59 | +10 | 14 | 8 | 1 | 18:42 | 2 | 12 | 0 | 170 | 12.4 | 4 | 44 | 0.74 | 49 | 1 |
| Matt Carle | D | BUF | 73 | 12 | 33 | 45 | +13 | 59 | 0 | 2 | 23:59 | 3 | 9 | 0 | 75 | 16.0 | 106 | 54 | 0.62 | - | 0 |
| Tyler Myers | D | BUF | 76 | 11 | 32 | 43 | +16 | 76 | 2 | 1 | 23:37 | 6 | 12 | 0 | 86 | 12.8 | 94 | 136 | 0.57 | - | 0 |
| Anders Lee | C | BUF | 81 | 23 | 19 | 42 | +9 | 69 | 3 | 2 | 17:50 | 2 | 7 | 0 | 176 | 13.1 | 3 | 163 | 0.52 | 38 | 0 |
| Michael Raffl | C | BUF | 82 | 20 | 19 | 39 | +8 | 48 | 1 | 2 | 15:35 | 4 | 8 | 0 | 185 | 10.8 | 15 | 135 | 0.48 | 50 | 0 |
| Jussi Jokinen | C | OTT / SJS / BUF | 80 | 11 | 26 | 37 | +1 | 16 | 1 | 2 | 13:58 | 4 | 10 | 0 | 118 | 9.3 | 6 | 63 | 0.46 | 55 | 0 |
| Eric Fehr | C | DAL / BUF | 83 | 17 | 18 | 35 | -7 | 27 | 2 | 1 | 14:37 | 4 | 9 | 0 | 172 | 9.9 | 12 | 64 | 0.42 | 51 | 0 |
| Mathieu Perreault | C | PHL / BUF | 63 | 12 | 22 | 34 | +2 | 22 | 3 | 0 | 16:49 | 0 | 2 | 0 | 125 | 9.6 | 6 | 79 | 0.54 | 54 | 0 |
| Luke Glendening | C | BUF | 82 | 14 | 18 | 32 | +10 | 49 | 2 | 4 | 13:36 | 1 | 1 | 3 | 132 | 10.6 | 19 | 81 | 0.39 | 54 | 0 |
| Riley Sheahan | C | BUF | 60 | 12 | 20 | 32 | +8 | 8 | 2 | 0 | 14:10 | 2 | 7 | 0 | 100 | 12.0 | 3 | 26 | 0.53 | 53 | 0 |
| Fedor Tyutin | D | MIN / SJS / BUF | 82 | 5 | 27 | 32 | -5 | 80 | 1 | 0 | 20:42 | 4 | 7 | 0 | 71 | 7.0 | 129 | 115 | 0.39 | - | 0 |
| Peter Holland | C | BUF / PHL | 71 | 12 | 9 | 21 | -2 | 22 | 2 | 1 | 11:07 | 0 | 0 | 0 | 99 | 12.1 | 8 | 51 | 0.30 | 49 | 0 |
| Eric Brewer | D | BUF | 81 | 1 | 19 | 20 | -6 | 79 | 0 | 0 | 18:13 | 1 | 4 | 0 | 45 | 2.2 | 68 | 155 | 0.25 | - | 0 |
| Vernon Fiddler | C | DAL / NYR / BUF | 64 | 7 | 12 | 19 | -8 | 10 | 1 | 0 | 14:23 | 2 | 3 | 0 | 124 | 5.6 | 11 | 31 | 0.30 | 54 | 0 |
| Patrick Dwyer | LW | BUF / DET | 52 | 8 | 9 | 17 | -1 | 12 | 2 | 1 | 14:46 | 0 | 1 | 1 | 79 | 10.1 | 13 | 46 | 0.33 | 28 | 0 |
| Rasmus Ristolainen (R) | D | BUF | 73 | 4 | 12 | 16 | +15 | 16 | 0 | 1 | 19:22 | 1 | 1 | 0 | 57 | 7.0 | 55 | 34 | 0.22 | 0 | 0 |
| Cedric Paquette | C | BUF | 42 | 8 | 7 | 15 | +12 | 28 | 1 | 0 | 11:46 | 0 | 0 | 0 | 58 | 13.8 | 3 | 49 | 0.36 | 50 | 0 |
| Kevan Miller | D | BUF | 68 | 4 | 11 | 15 | -7 | 59 | 1 | 0 | 16:48 | 0 | 1 | 0 | 35 | 11.4 | 89 | 52 | 0.22 | - | 0 |
| Brad Stuart | D | MTL / BUF | 67 | 3 | 12 | 15 | +5 | 66 | 0 | 0 | 19:17 | 0 | 0 | 0 | 39 | 7.7 | 88 | 166 | 0.22 | - | 0 |
| Paul Gaustad | C | BUF | 69 | 3 | 12 | 15 | -1 | 41 | 0 | 0 | 11:05 | 0 | 0 | 0 | 79 | 3.8 | 9 | 68 | 0.22 | 58 | 0 |
| Paul Byron | C | BUF | 61 | 5 | 6 | 11 | -9 | 17 | 0 | 1 | 9:10 | 0 | 0 | 0 | 60 | 8.3 | 6 | 31 | 0.18 | 39 | 0 |
| Brett Bellemore | D | BUF | 69 | 1 | 10 | 11 | 0 | 88 | 1 | 0 | 13:52 | 1 | 1 | 0 | 16 | 6.2 | 51 | 144 | 0.16 | - | 0 |
| Jacob Josefson | C | BUF | 38 | 1 | 4 | 5 | -2 | 4 | 0 | 0 | 9:27 | 0 | 0 | 0 | 24 | 4.2 | 5 | 14 | 0.13 | 47 | 0 |
| Rickard Rakell (R) | C | BUF | 22 | 0 | 4 | 4 | -3 | 4 | 0 | 0 | 10:42 | 0 | 0 | 0 | 20 | 0.0 | 2 | 8 | 0.18 | 50 | 0 |
| Brayden McNabb | D | BUF | 15 | 1 | 2 | 3 | +3 | 6 | 0 | 0 | 9:56 | 0 | 1 | 0 | 3 | 33.3 | 4 | 10 | 0.20 | - | 0 |
| Jerry D'Amigo | LW | BUF | 16 | 1 | 1 | 2 | 0 | 6 | 0 | 1 | 7:43 | 0 | 0 | 0 | 11 | 9.1 | 2 | 2 | 0.13 | 40 | 0 |
| 29 Skaters | 1893 | 297 | 536 | 833 | - | 980 | 48 | 27 | - | 51 | 141 | 4 | 2924 | - | 834 | 1991 | 11.7 | - | 1 |