| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | PPP | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Thomas Vanek | LW | BUF | 82 | 48 | 45 | 93 | +32 | 16 | 5 | 2 | 20:15 | 10 | 22 | 0 | 375 | 12.8 | 9 | 33 | 1.13 | 35 | 1 |
| Dustin Brown | LW | BUF | 82 | 31 | 46 | 77 | +34 | 70 | 3 | 1 | 23:54 | 9 | 20 | 3 | 308 | 10.1 | 20 | 219 | 0.94 | 37 | 2 |
| Brian Campbell | D | BUF | 82 | 14 | 53 | 67 | +3 | 16 | 2 | 0 | 26:53 | 11 | 30 | 0 | 154 | 9.1 | 127 | 22 | 0.82 | - | 0 |
| Sidney Crosby | C | BUF | 55 | 22 | 43 | 65 | +21 | 10 | 7 | 1 | 20:57 | 5 | 21 | 0 | 208 | 10.6 | 9 | 17 | 1.18 | 57 | 0 |
| Cody Eakin | C | BUF | 81 | 15 | 29 | 44 | +1 | 6 | 2 | 1 | 15:10 | 3 | 14 | 0 | 175 | 8.6 | 3 | 11 | 0.54 | 50 | 0 |
| Matt Cullen | C | BUF | 69 | 10 | 33 | 43 | +10 | 7 | 1 | 1 | 18:29 | 1 | 11 | 0 | 155 | 6.5 | 14 | 3 | 0.62 | 59 | 0 |
| Tyler Myers | D | BUF | 82 | 11 | 21 | 32 | +1 | 64 | 1 | 0 | 23:10 | 5 | 13 | 0 | 70 | 15.7 | 104 | 101 | 0.39 | - | 0 |
| Cal Clutterbuck | LW | BUF | 82 | 15 | 16 | 31 | 0 | 113 | 6 | 1 | 16:13 | 5 | 10 | 1 | 112 | 13.4 | 4 | 234 | 0.38 | 27 | 0 |
| Victor Bartley (R) | D | BUF | 82 | 8 | 20 | 28 | +4 | 48 | 3 | 0 | 18:11 | 4 | 8 | 0 | 64 | 12.5 | 71 | 50 | 0.34 | - | 0 |
| Paul Gaustad | C | BUF | 52 | 7 | 12 | 19 | +17 | 31 | 2 | 0 | 15:46 | 1 | 2 | 0 | 75 | 9.3 | 7 | 29 | 0.37 | 60 | 0 |
| Luca Sbisa | D | BUF | 65 | 1 | 18 | 19 | +17 | 83 | 0 | 0 | 18:32 | 0 | 3 | 0 | 37 | 2.7 | 43 | 161 | 0.29 | - | 0 |
| Patrick Kaleta | RW | BUF | 82 | 8 | 10 | 18 | -2 | 65 | 0 | 0 | 11:43 | 1 | 1 | 0 | 80 | 10.0 | 7 | 156 | 0.22 | 31 | 0 |
| Travis Moen | LW | ANH / NJD / BUF | 79 | 6 | 11 | 17 | -4 | 32 | 2 | 0 | 9:59 | 0 | 0 | 0 | 77 | 7.8 | 5 | 68 | 0.22 | 42 | 0 |
| Manny Malhotra | C | TBL / BOS / BUF | 47 | 9 | 7 | 16 | -12 | 4 | 1 | 0 | 16:44 | 0 | 1 | 0 | 45 | 20.0 | 11 | 7 | 0.34 | 60 | 0 |
| Anton Volchenkov | D | BUF | 70 | 4 | 10 | 14 | +24 | 102 | 0 | 1 | 19:02 | 1 | 3 | 0 | 34 | 11.8 | 80 | 204 | 0.20 | - | 0 |
| Mike Weber | D | BUF | 68 | 2 | 12 | 14 | 0 | 201 | 1 | 0 | 16:00 | 0 | 0 | 0 | 30 | 6.7 | 65 | 165 | 0.21 | - | 0 |
| Steve Oleksy | D | NJD / BUF | 82 | 1 | 13 | 14 | -20 | 65 | 0 | 0 | 15:07 | 0 | 1 | 0 | 27 | 3.7 | 77 | 93 | 0.17 | - | 0 |
| Marty Reasoner | C | BUF / DAL | 78 | 7 | 6 | 13 | -20 | 6 | 4 | 1 | 10:56 | 1 | 2 | 0 | 63 | 11.1 | 7 | 20 | 0.17 | 52 | 0 |
| Brett Clark | D | BUF / CHI / CLB | 51 | 2 | 8 | 10 | -1 | 36 | 0 | 0 | 14:13 | 1 | 3 | 0 | 25 | 8.0 | 36 | 43 | 0.20 | - | 0 |
| Chris Thorburn | C | BUF / VAN | 68 | 5 | 3 | 8 | -14 | 59 | 1 | 0 | 12:06 | 0 | 0 | 0 | 44 | 11.4 | 3 | 85 | 0.12 | 47 | 0 |
| Darroll Powe | C | BUF | 78 | 4 | 4 | 8 | -11 | 24 | 0 | 0 | 10:31 | 0 | 0 | 0 | 69 | 5.8 | 11 | 42 | 0.10 | 40 | 0 |
| Andrew Desjardins | C | BUF / NJD | 80 | 5 | 1 | 6 | -12 | 28 | 0 | 1 | 8:57 | 0 | 0 | 0 | 35 | 14.3 | 4 | 47 | 0.08 | 57 | 0 |
| Jacob Josefson | C | BUF | 46 | 1 | 4 | 5 | -1 | 0 | 0 | 0 | 8:07 | 0 | 0 | 0 | 39 | 2.6 | 3 | 6 | 0.11 | 56 | 0 |
| Adrian Aucoin | D | BUF / FLA | 30 | 1 | 2 | 3 | -6 | 26 | 0 | 0 | 13:03 | 0 | 0 | 0 | 11 | 9.1 | 25 | 35 | 0.10 | - | 0 |
| Jeremy Morin (R) | LW | BUF | 4 | 1 | 1 | 2 | +1 | 0 | 0 | 0 | 14:10 | 0 | 0 | 0 | 4 | 25.0 | 0 | 0 | 0.50 | 33 | 0 |
| John Scott | LW | BUF / PHL | 18 | 1 | 0 | 1 | -2 | 12 | 0 | 0 | 10:41 | 0 | 0 | 0 | 2 | 50.0 | 4 | 28 | 0.06 | - | 0 |
| Paul Byron (R) | C | BUF | 34 | 0 | 1 | 1 | -2 | 0 | 0 | 0 | 5:31 | 0 | 0 | 0 | 10 | 0.0 | 2 | 8 | 0.03 | 17 | 0 |
| Luke Adam | C | BUF | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0:26 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0.00 | - | 0 |
| Ryan Stanton (R) | D | BUF | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0:33 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0.00 | - | 0 |
| Kevin Henderson (R) | LW | BUF | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0 | 0 | - | 0 | 0 | 0.00 | - | 0 |
| Brett Bellemore (R) | D | BUF | 5 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0:09 | 0 | 0 | 0 | 0 | - | 0 | 1 | 0.00 | - | 0 |
| Luke Glendening (R) | C | BUF | 5 | 0 | 0 | 0 | -1 | 0 | 0 | 0 | 7:37 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0.00 | 0 | 0 |
| 32 Skaters | 1747 | 239 | 429 | 668 | - | 1126 | 41 | 10 | - | 58 | 165 | 4 | 2328 | - | 751 | 1888 | 9.83 | - | 3 |