| Skater | Pos | Team | GP | G | A | P | +/- | PiM | GW | GT | ATOI | PPG | SHG | S | S% | BkS | Hits | P/GP | FO% | HT |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sidney Crosby | C | BUF | 81 | 37 | 56 | 93 | +38 | 63 | 5 | 2 | 18:02 | 12 | 0 | 319 | 11.6 | 9 | 111 | 1.15 | 59 | 0 |
| Marian Gaborik | RW | BUF | 80 | 37 | 44 | 81 | +30 | 26 | 4 | 2 | 16:26 | 15 | 0 | 292 | 12.7 | 11 | 49 | 1.01 | 31 | 0 |
| Derek Roy | C | BUF | 74 | 23 | 47 | 70 | +18 | 32 | 3 | 2 | 19:26 | 6 | 0 | 231 | 10.0 | 17 | 85 | 0.95 | 53 | 0 |
| Thomas Vanek | LW | BUF | 82 | 25 | 44 | 69 | +23 | 39 | 9 | 2 | 16:42 | 7 | 0 | 257 | 9.7 | 6 | 64 | 0.84 | 36 | 0 |
| Jason Pominville | RW | BUF | 80 | 33 | 34 | 67 | +26 | 22 | 6 | 0 | 18:04 | 8 | 1 | 206 | 16.0 | 11 | 45 | 0.84 | 39 | 0 |
| Tyler Myers (R) | D | BUF | 82 | 12 | 40 | 52 | +22 | 50 | 1 | 1 | 23:02 | 9 | 0 | 126 | 9.5 | 98 | 87 | 0.63 | - | 0 |
| Anton Volchenkov | D | BUF | 72 | 10 | 31 | 41 | +31 | 207 | 1 | 0 | 21:03 | 3 | 0 | 75 | 13.3 | 111 | 192 | 0.57 | - | 0 |
| Colby Armstrong | LW | BUF | 82 | 16 | 20 | 36 | +36 | 110 | 0 | 5 | 17:15 | 9 | 1 | 109 | 14.7 | 12 | 101 | 0.44 | 35 | 0 |
| Mark Giordano | D | ANH / BUF | 75 | 11 | 25 | 36 | +6 | 156 | 2 | 0 | 21:23 | 8 | 0 | 90 | 12.2 | 99 | 166 | 0.48 | - | 0 |
| Mike Grier | RW | BUF | 80 | 17 | 16 | 33 | +5 | 22 | 4 | 1 | 15:14 | 0 | 0 | 152 | 11.2 | 10 | 32 | 0.41 | 39 | 0 |
| Mike Mottau | D | BUF | 76 | 8 | 24 | 32 | +25 | 55 | 1 | 1 | 19:22 | 4 | 0 | 68 | 11.8 | 85 | 74 | 0.42 | - | 0 |
| Henrik Tallinder | D | BUF | 64 | 4 | 24 | 28 | 0 | 50 | 0 | 0 | 20:27 | 2 | 1 | 44 | 9.1 | 84 | 40 | 0.44 | - | 0 |
| Paul Gaustad | C | BUF | 81 | 11 | 15 | 26 | +4 | 131 | 2 | 2 | 15:44 | 0 | 0 | 108 | 10.2 | 21 | 117 | 0.32 | 58 | 0 |
| Steve Montador | D | BUF | 81 | 7 | 18 | 25 | +4 | 150 | 4 | 1 | 15:51 | 3 | 0 | 61 | 11.5 | 33 | 118 | 0.31 | - | 0 |
| Hal Gill | D | BUF | 64 | 7 | 16 | 23 | +14 | 110 | 3 | 0 | 16:53 | 4 | 0 | 37 | 18.9 | 88 | 103 | 0.36 | - | 0 |
| Cody McLeod | LW | BUF | 82 | 4 | 16 | 20 | +4 | 75 | 0 | 0 | 9:58 | 0 | 0 | 75 | 5.3 | 9 | 95 | 0.24 | 38 | 0 |
| Kirk Maltby | LW | BUF | 80 | 4 | 8 | 12 | -1 | 34 | 0 | 1 | 10:38 | 0 | 0 | 56 | 7.1 | 8 | 56 | 0.15 | 44 | 0 |
| Scott Nichol | C | BUF | 80 | 6 | 5 | 11 | -2 | 52 | 2 | 1 | 10:37 | 0 | 0 | 50 | 12.0 | 11 | 89 | 0.14 | 58 | 0 |
| Chris Thorburn | RW | BUF | 82 | 3 | 6 | 9 | +1 | 46 | 1 | 0 | 7:11 | 0 | 0 | 54 | 5.6 | 5 | 25 | 0.11 | 29 | 0 |
| Chris Butler (R) | D | BUF | 43 | 1 | 6 | 7 | +6 | 36 | 0 | 0 | 17:00 | 0 | 0 | 17 | 5.9 | 24 | 46 | 0.16 | - | 0 |
| Patrick Kaleta | RW | BUF | 7 | 0 | 1 | 1 | +1 | 8 | 0 | 0 | 10:17 | 0 | 0 | 7 | 0.0 | 0 | 6 | 0.14 | 60 | 0 |
| Luca Sbisa (R) | D | BUF | 3 | 0 | 0 | 0 | +2 | 2 | 0 | 0 | 18:40 | 0 | 0 | 0 | - | 3 | 4 | 0.00 | - | 0 |
| Tim Kennedy (R) | LW | BUF | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0 | 0.00 | - | 0 |
| 23 Skaters | 1535 | 276 | 496 | 772 | - | 1476 | 48 | 21 | - | 90 | 3 | 2434 | - | 755 | 1705 | 10.11 | - | 0 |